Model for solvent viscosity effect on enzymatic reactions

Model for solvent viscosity effect on enzymatic reactions

Why reaction rate constants for enzymatic reactions are typically inversely proportional to fractional power exponents of solvent viscosity remains to be already a thirty years old puzzle. Available interpretations of the phenomenon have not led to consensus among researches about its origin. They invoke to either a modification of 1. the conventional Kramers’ theory or that of 2. the Stokes la...

Solvent viscosity dependence for enzymatic reactions

A mechanism for relationship of solvent viscosity with reaction rate constant at enzyme action is suggested. It is based on fluctuations of electric field in enzyme active site produced by thermally equilibrium rocking (cranckshaft motion) of the rigid plane (in which the dipole moment ≈ 3.6 D lies) of a favourably located and oriented peptide group (or may be a few of them). Thus the rocking o...

Enzymatic Reactions

It has been argued that a substrate-induced conformational change involving the orientation of catalytic groups cannot affect the specificity for two substrates in an enzymatic system where the chemical step is rate limiting, because such an induced fit would alter the catalytic efficiency for both to an equal extent. To the contrary, the generalized induced-fit treatment described here shows t...

Greener Solvent-Free Reactions on ZnO

Attaching Biochemical Information on Putative Enzymatic Reactions

A cellular system is composed of a considerable number of elements including genes, proteins or enzymes, and metabolites. They are dynamically connected and interdependent to construct a network diagram, which is referred to as a metabolic pathway. The significance of a systems approach has been recognized for understanding the activities of living organisms (Eisenberg et al., 2000; Kanehisa, 2...